Therapeutic efficacy of insulin aspart combined with insulin detemir in treatment of pediatric diabetes mellitus
Objective To investigate the therapeutic efficacy of levemir combined with novorapid in the treatment of pediatric diabetes mellitus.Methods One hundred and thirty-eight children with pediatric type 1 diabetes mellitus admitted to Tianjin Children's Hospital(Children's Hospital of Tianjin University)from November 2022 to August 2023 were selected as the subjects and divided into two groups using the random number table method,with 69 in each.The children in the control group received isophane protamine biosynthetic human insulin injection,while those in the study group were given insulin aspart combined with insulin detemir.Then the therapeutic efficacy,blood glucose,blood lipid and the occurrence of hypoglycaemia were compared between the two groups.Results After treatment,the study group reported a higher therapeutic efficacy rate as compared with the control(91.30%vs 72.47%,χ2=8.256,P<0.05).A reduction was found in glycosylated haemoglobin,fasting blood glucose and 2-hour postprandial blood glucose in all patients after treatment,and the reduction was more notable in the observation group than in the control((6.03±1.20)%vs(7.67±1.49)%,(6.14±1.32)mmol·L-1 vs(7.34±2.06)mmol·L-1,(7.55±2.01)mmol·L-1 vs(9.36±3.15)mmol·L-1,t=7.121,4.074,4.024,all P<0.05).An increase in high-density lipoprotein cholesterol and a decrease in low-density lipoprotein cholesterol,total cholesterol and triglycerides were detected in all patients after treatment,and both improvements were more notable in the observation group than in the control((1.72±0.63)mmol·L-1 vs(1.38±0.47)mmol·L-1,(4.31±0.65)mmol·L-1 vs(5.26±0.74)mmol·L-1,(1.59±0.85)mmol·L-1 vs(2.25±0.94)mmol·L-1,(1.44±0.47)mmol·L-1 vs(2.06±0.54)mmol·L-1,t=3.593,8.012,4.326,7.194,all P<0.05).After treatment,the frequency and number of hypoglycemia incidence were(0.75±0.17)times/week and 8.70%in the observation group,which were lower than those of(1.19±0.21)times/week and 28.99%in the control(t=13.527,χ2=9.289,all P<0.05).The level of hypoglycemia was(3.58±0.16)mmol·L-1 in the observation group,which was higher than that of(3.13±0.18)mmol·L-1 in the control(t=15.521,P<0.05).Conclusion Application of insulin aspart combined with insulin detemir in the treatment of pediatric diabetes has good efficacy and safety profile,which can effectively improve the glycolipid metabolism.
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