Objective To investigate the effect of rivaroxaban on postoperative bleeding and deep vein thrombosis(DVT)in patients undergoing laparoscopic hernia repair.Methods One hundred and twenty-two patients who underwent laparoscopic inguinal repair in Shaoxing People's Hospital from March 2021 to September 2023 were selected,and randomly grouped,with 61 cases in each group.Control group was given low molecular weight heparin treatment,and observation group was given rivaroxaban treatment.Then the parameters for coagulation/fibrinolysis,postoperative bleeding events and DVT were compared between two groups.Results After treatment,fibrinogen(FIB),prothrombin time(PT),and activated partial thromboplastin time(APTT)decreased in all patients(P<0.05),and the decrease was more table in observation group compared to control group((3.08±0.51)g·L-1 vs(1.92±0.46)g·L-1,(12.02±1.19)s vs(10.05±1.27)s,(31.68±3.42)s vs(25.82±3.36)s,t=13.191,8.841,9.546,all P<0.05).An increase was observed in D-dimer(D-D),tissue-type plasminogen activator(t-PA)and plasminogen activator inhibitor 1(PAI-1)in all patients after treatment(all P<0.05),and the levels of D-D and PAI-1 in the observation group((7.98±1.47)mg·L-1,(33.92±6.19)ng·L-1)was lower than that in the control group((11.75±1.68)mg·L-1,(39.72±6.73)ng·L-1)(t=13.190,4.954,both P<0.05),the level of t-PA in the observation group was higher than that in the control group((13.02±1.83)ng·L-1 vs(11.59±1.79)ng·L-1,t=4.363,P<0.05).No statistical difference was found in incidence of bleeding events and thrombosis between two groups(8.20%vs 4.91%,0%vs 4.91%,χ2=0.480,1.367,both P>0.05).Conclusion Rivaroxaban is effective and safe in improving coagulation and reducing the occurrence of DVT in patients undergoing laparoscopic inguinal repair.
Inguinal herniaLaparoscopic inguinal hernia repairRivaroxabanLow molecular weight heparinThrombusCoagulation function
NETL
NSTL
万方数据
