Evaluation of efficacy of nebulized triple therapy on patients undergoing lobectomy for lung cancer and its impact on lung function and prognosis
Objective To explore the efficacy of nebulized triple therapy on patients undergoing lobectomy for lung cancer and its impact on lung function and prognosis.Methods Lung cancer patients selected from 196 cases of thoracoscopic lobectomy treatment in the Sixth People's Hospital of Nantong City from January 2020 to November 2023 were divided into 2 groups according to the difference of postoperative nebulized drμg treatment.The study group consisted of 100 patients treated with nebulized inhalation of budesonide,formoterol,and acetylcysteine,while the control group included 96 patients treated with nebulized inhalation of budesonide combined with formoterol during surgery.The differences in clinical efficacy between 2 groups were compared.Results After treatment,the duration of coμgh relief,reduction of moist rale and postoperative hospitalization in the study group((5.5±1.1)d,(6.5±1.2)d,(8.0±1.5)d,respectively)were shorter than those in the control group((8.7±1.5)d,(7.6±1.4)d,(10.8±2.5)d,respectively).The difference was statistically significant(t=17.080,5.914,9.552,all P<0.05).After treatment,the complication rate of the study group was 2.0%(2/100),and that of the control group was 2.1%(2/96)(χ2=0.002,P=0.967).After treatment,the maximum gas volume(MVV),maximum expiratory flow rate(PEF),ratio of forced expiratory volume to forced vital capacity(FEV1/FVC)in the first second of study group and control group were((85.0±11.1)L,(78.3±9.9)L;(3.8±1.1)L·s-1,(2.7±0.7)L·s-1;(82.9±10.5)%,75.7±8.8)%)were higher than before treatment((62.4±8.0)L,(62.1±8.5)L;(2.0±0.6)L·s-1,2.1±0.5)L·s-1;(60.7±8.9)%,(60.3±7.7)%),and the study group was higher than the control group.The difference was statistically significant(t=4.327,5.011,4.490,all P<0.05).After treatment,C-reactive protein(CRP)and procalcitonin(PCT)in study group and control group((9.5±1.7)mg·L-1,(13.7±1.5)mg·L-1;(3.3±0.6)μg·L-1,(4.2±1.1)μg·L-1,respectively),It was lower than before treatment(18.3±2.5)mg·L-1,(18.5±2.7)mg·L-1;(5.4±1.0)μg·L-1,(5.3±1.2)μg·L-1),respectively),and the study group was lower than the control group,the difference was statistically significant(t=11.512,13.809,both P<0.05).After treatment,the FACT-L scores of study group and control group((81.0±8.3)points and(70.2±8.2)points,respectively)were higher than those before treatment((49.5±7.5)points and(49.4±5.9)points,respectively),and the difference was statistically significant(t=9.163,P<0.05).Conclusion Nebulized inhalation of budesonide,formoterol,and acetylcysteine helps improve lung function in patients undergoing lobectomy for lung cancer,reduces levels of inflammatory factors,alleviates inflammatory reactions,and enhances patient quality of life.These findings are worthy of clinical reference.
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