Analysis of efficacy and adverse reactions of methotrexate combined with glucocorticoids in treatment of granulomatous lobular mastitis
Objective To investigate the efficacy and adverse reactions of methotrexate combined with glucocorticoids in the treatment of granulomatous lobular mastitis(GLM).Methods The clinical data of 99 patients with GLM treated in Guangdong Provincial Hospital of Traditional Chinese Medicine and Guangdong Maternal and Child Health Hospital from September 2019 to December 2021 were retrospectively analyzed.According to the patient's treatment plan,34 patients treated with methotrexate combined with glucocorticoids were enrolled in the combined group and 65 patients treated with glucocorticoids alone were included in the control group.The inflammatory factor levels,treatment effect and incidence of adverse reactions were compared between the two groups.Results After treatment,the total effective rate was 97.06%(33/34)in the combined group,which was higher than that of 80.00%(52/65)in the control(χ2=4.038,P<0.05).The levels of C-reactive protein(CRP),interleukin-6(IL-6)and white blood cell count(WBC)after treatment in the combined group and the control group were((19.78±4.74)mg·L-1,(26.46±4.24)mg·L-1;(22.68±5.81)pg·mL-1,(33.52±6.22)pg·mL-1;(7.14±0.84)109·mL-1,(8.64±0.97)109·mL-1),respectively,which were lower than those before treatment((34.46±8.24)mg·L-1,(33.52±7.81)mg·L-1;(39.77±10.24)pg·mL-1,(40.13±11.05)pg·mL-1;(10.54±2.24)109·mL-1,(10.72±2.51)109·mL-1).Meanwhile,they were significantly lower in the combined group than in the control(t=7.146,8.419,7.638,all P<0.05).The incidence of adverse reactions in the combined group was 11.76%(4/34),which was lower than that of 30.77%(20/65)in the control group(χ2=4.390,P<0.05).Conclusion The treatment regimen of methotrexate combined with glucocorticoids can significantly alleviate the clinical symptoms of patients with GLM.Furthermore,it is highly safe and has clinical application value.
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