Clinical evaluation of Puyuanhewei capsule combined with rabeprazole in treatment of reflux esophagitis
Objective To investigate the efficacy of Puyuanhewei capsule combined with rabeprazole in the treatment of reflux esophagitis.Methods A total of 102 patients with reflux esophagitis admitted to the First Affiliated Hospital of Henan University from June 2022 to January 2024 were divided into the observation group(n=51)and control group(n=51)by random number table method.Patients in the control group were given rabeprazole treatment while those in the observation group were given Puyuanhewei capsule combined with rabeprazole treatment.The efficacy,relief time of epigastric pain,pantothenic acid and belching symptoms were compared between the two groups.Reflux disease questionnaire(RDQ)score before and after treatment,levels of motilin and gastrin and treatment adverse reactions were also compared.Results The total effective rate was significantly higher in the observation group than in the control(96.08%vs 84.31%,χ2=3.991 P<0.05).The relief time of epigastric pain,pantothenic acid and belching in the observation group were(6.15±0.52)d,(5.80±0.52)d and(5.52±0.38)d,respectively,which were shorter than those of(8.44±0.73)d,(7.38±0.66)d and(6.72±0.82)d in the control(t=18.247,13.429,9.482,P<0.001).Symptom frequency score and symptom severity score of the observation group were(3.99±0.52)points and(5.48±0.69)points after treatment and both of them were shorter than those of(6.24±0.67)points and(7.42±0.72)points of the control(t=18.946,13.893,P<0.001).After treatment,the levels of motilin and gastrin in observation group were(331.29±4.92)ng·L-1 and(178.54±4.37)pg.mL-1,respectively,which were lower than those of(299.54±5.23)ng·L-1 and(143.25±4.92)pg·mL-1 in the control(t=31.577,38.298,P<0.001).The adverse reaction rate of observation group was similar to that of the control(3.92%vs 5.88%,χ2=0.210,P>0.05).Conclusion The combination of Puyuanhewei capsule with rabeprazole has a good effect in the treatment of reflux esophagitis since the symptoms of patients are relieved,the gastrointestinal function recovers well and the treatment side effects are less.
Reflux esophagitisPuyuanhewei capsuleRabeprazoleCurative effectDuration of symptom remissionReflux disease questionnaireAdverse reaction
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