Analysis of drug use in erlotinib induced interstitial pneumonia
An 83-year-old female patient was admitted due to diagnosis of advanced lung adenocarcinoma for 9 days and diagnosed with right lung adenocarcinoma(cT2N2M1c Ⅳ B).After admission,results of the gene test showed a common EGFR mutation(exon 19 deletion)and erlotinib hydrochloride tablets(150 mg,qd)were given to her.Ten days later,she developed interstitial pneumonia(IP).Clinical pharmacists recommended giving prednisolone(1.0-2.0 mg·kg-1·d-1)based on the patient's condition and literature review.She took osimertinib tablets(80 mg,qd)after recovery.And she developed IP again,which was improved after giving prednisolone again and withdrawl of osimertinib.The patient was discharged in good condition.Clinical pharmacists can provide valuable references for clinical rational drug use by deeply analyzing the medication problems.
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