Effect of ceftriaxone combined with glucocorticoids on ciliary clearance function and micro-inflammatory factors in elderly patients with severe pneumonia
Objective To investigate the effect of ceftriaxone combined with glucocorticoids on mucociliary clearance and microinflammatory state in elderly patients with severe pneumonia.Methods A total of 110 elderly patients with severe pneumonia treated in Luzhou Hospital of Traditional Chinese Medicine from May 2022 to October 2023 were prospectively selected as the subjects of this trial.They were randomly divided into two groups using a random number table method.The control group of 55 patients received treatment with ceftriaxone,while the study group of 55 patients received treatment with glucocorticoids in addition to the regimen in the control.The clinical efficacy,respiratory tract cilia clearance function,microinflammatory state,blood gas indicators and adverse reaction rate were compared between the two groups.Results The total effective rate of the treatment group was significantly higher than that of the control(94.55%vs 76.36%,χ2=7.314,P=0.007).After treatment,the nasal mucociliary clearance rate,nasal mucociliary clearance speed,nasal mucociliary transport speed,transforming growth factor-β level,and arterial blood oxygen partial pressure level were(68.12±4.78,76.23±4.56)%,(6.54±0.24,7.23±0.21)mm·min-1,(9.23±2.06,11.18±2.26)mm·min-1,(259.52±45.72,279.62±40.42)pg·mL-1,(81.42±10.39,86.59±9.24)mm Hg(1 mm Hg≈0.133 kPa),respectively.They were higher than those before treatment((44.74±3.97,44.62±4.01)%,(3.42±0.31,3.37±0.36)mm·min-1,(6.40±0.16,6.35±0.24)mm·min-1,(174.29±28.36,166.79±26.84)pg·mL-1,(60.43±6.89,60.08±6.47)mm Hg).Meanwhile,these indexes were higher in the observation group than in the control,showing statistical obvious differences(t=9.104,16.046,4.617,2.443,2.758,all P＜0.05).The levels of C-reactive protein,procalcitonin and arterial partial pressure of carbon dioxide in the observation group were(25.48±3.42,19.28±2.69)mg·L-1,(2.39±0.45,1.45±0.39)ng·mL-1,(41.48±6.39,38.39±5.89)mm Hg,respectively,and they were lower than those of(52.25±7.46,51.72±7.01)mg·L-1,(7.01±1.39,7.19±1.31)ng·mL-1,(56.13±7.23,55.68±8.11)mm Hg in the control and the difference was statistically obvious(t=10.567,11.707,2.637,all P＜0.05).There was no significant difference in the incidence of adverse reactions between the observation group(12.73%)and the control group(9.09%)(χ2=0.374,P=0.541).Conclusion Ceftriaxone combined with glucocorticoids is effective in the treatment of severe pneumonia because it can improve the cilia clearance function of respiratory tract and micro inflammatory state and optimize blood gas indexes.
Severe pneumoniaCeftriaxoneGlucocorticoidMucociliary clearanceMicro-inflammatory factor
万方数据
维普
