Effect of trimetazidine combined with metoprolol on myocardial remodeling and expression of inflammatory cytokines in patients with hypertension and diabetes mellitus
Objective To investigate the effect of trimetazidine combined with metoprolol on myocardial remodeling and inflammatory cytokine expression in patients with hypertension and diabetes mellitus.Methods A total of 96 patients with hypertension and diabetes mellitus admitted to Guangfu Cancer Hospital from January 2021 to June 2022 were selected as subjects and divided into the control group(n=48)and study group(n=48)according to the random number table method.The patients in the control group were treated with conventional hypoglycemic and metoprolol and those in the study group with trimetazidine on the basis of treatment regimen in the control group.Blood pressure,blood glucose,myocardial remodeling indexes,N-terminal pro-B-type natriuretic peptide(NT-ProBNP),endothelin-1(ET-1),nitric oxide(NO),angiotensin Ⅱ(AngⅡ)levels and inflammatory cytokine levels were detected and compared between the two groups before and after treatment.The incidence of adverse reactions during treatment was counted.Results After treatment,systolic blood pressure and diastolic blood pressure in the study group were lower than those in the control group((125.46±5.84)mm Hg(1 mm Hg≈0.133 kPa)vs(134.06±6.74)mm Hg,(78.74±5.33)mm Hg vs(84.64±5.14)mm Hg,t=6.681,5.520,both P＜0.05).The indexes of blood glucose and myocardial remodeling of patients in the study group were lower than those in the control group(all P＜0.05).NT-ProBNP((120.21±14.08)pg·mL-1),ET-1((1.47±0.12)ng·L-1)and Ang Ⅱ((76.45±14.85)ng·L-1 in the study group were lower than those in the control group((148.56±16.33)pg·mL-1,(2.24±0.36)ng·L-1,(86.51±15.22)ng·L-1,t=9.109,14.058,3.278,all P＜0.05).However,the NO in the study group was higher than that in the control group((58.54±5.71)μmol·L-1 vs(48.18±4.66)μmol·L-1,t=9.739,P＜0.05).The levels of hs-CRP and TNF-α in the study group were lower than those in the control group(t=2.482,4.321,both P＜0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion Trimetazidine combined with metoprolol has a good antihypertensive and hypoglycemic effect on patients with hypertension and diabetes mellitus since it can effectively improve myocardial remodeling and reduce inflammatory response.Meanwhile,it is of high safety.
万方数据
维普
