Comparison of effect of using propofol or dexmedetomidine alone with their combined use on hemodynamic parameters and time to awakening in patients after general anesthesia
Objective To compare the effect of propofol or dexmedetomidine alone with that of their combined use on hemodynamic indexes and wake time in patients after general anesthesia.Methods Patients who came to the Third Affiliated Hospital of Anhui Medical University for general anesthesia from June 2018 to June 2020 were divided into three groups of the propofol group,dexmedetomidine group and combination group using the random number table method.Time to awakening and that to extubation were recorded for all patients.The heart rate(HR),systolic blood pressure(SBP),diastolic blood pressure(DBP),mean arterial pressure(MAP),anesthesia depth index(BIS)and cerebral state index(CSI)before anesthesia induction(T0),before intubation(T1),1 minute after intubation(T2),before skin incision(T3),and 3 minutes after extubation(T4)were compared among the three groups.The Riker sedation restlessness score(SAS)and incidence of adverse reactions were also compared among the three groups.Results The extubation time((11.50±2.44)min)and recovery time((24.56±5.21)min)of patients in the dexmedetomidine group were significantly longer than those in the propofol group((9.03±3.12)min,(20.43±3.45)min)and the combination group((8.91±2.31)min,(19.25±4.10)min)(F=9.291,11.024,both P＜0.05).The SAS score of the propofol group(5.83±0.92)was significantly higher than that of dexmedetomidine group(4.42±0.52)and combination group(4.39±0.47)(P＜0.05).The hemodynamic parameters(HR,SBP,DBP,and MAP)in the propofol group were significantly more affected by intubation and extubation than those in the dexmedetomidine group and the combination group(F=6.436,P＜0.05).The BIS and CSI indices of the three groups were all between 40 and 60,indicating that anesthesia could proceed smoothly.The incidence of adverse reactions in the combination group(8.00%)was significantly lower than that in the propofol group(27.08%)and the dexmedetomidine group(26.92%)(χ2=7.954,P＜0.05).Conclusion Dexmedetomidine combined with propofol can stabilize hemodynamic fluctuations,reduce wake-up time and decrease the incidence of adverse effects.
General anesthesiaLaparoscopic surgeryDexmedetomidinePropofolHemodynamics
万方数据
维普
