Effect of sevoflurane anesthesia on perioperative indexes in patients undergoing brain tumor resection
Objective To investigate the effect of sevoflurane anesthesia on perioperative indexes in patients undergoing brain tumor resection.Methods Fifty patients admitted to the Affiliated Hospital of North China University of Technology for brain tumor resection from May 2020 to May 2021 were selected as the subjects and divided into two groups using random sampling method,with 25 in each group.The patients in the control group were anesthetized with propofol and those in the study group with sevoflurane.The quality of awakening,serum neuron-specific enolase(NSE),and S100 calcium-binding protein β(S100β)levels at different time points(24 h before surgery(T0),after induction of anesthesia(T1),after incision of the dura mater(T2),at the end of surgery(T3),and at 24 h after surgery(T4)),serum factor levels(tumor necrosis factor-alpha(TNF-α),and interleukin-6(IL-6))at different time points(T0,T4),and the mini-mental state examination(MMSE)score at different time points(24 h before,6 h after,24 h after,and 72 h after)were compared between the two groups,and the rates of adverse reactions were calculated in both groups.Results The recovery time and extubation time in the study group were both shorter than those in the control group((25.04±5.94)min vs(29.37±7.18)min,(30.48±8.13)min vs(37.26±10.52)min)(t=2.323,2.550,both P＜0.05).There were no statistically significant differences in serum NSE and S100 β levels between the two groups at T0 and T1(both P＞0.05).Compared with T0 time point,the serum NSE and S100 β levels in the study group and control group at T2,T3,and T4 time points increased respectively,and the serum NSE and S100 β levels in the study group at T2,T3,and T4 time points were all lower than those in the control group(all P＜0.05).At T0 time point,there were no statistically significant differences in the levels of serum TNF-α and IL-6 between the two groups(P＞0.05).At T4 time point,the levels of serum TNF-α and IL-6 in both groups were higher than those at T0 time point,and the levels of serum TNF-α and IL-6 in the study group were both lower than those in the control group(all P＜0.05).There was no statistically significant difference in MMSE scores 24 hours before surgery between the two groups(P＞0.05).However,at 6 hours and 24 hours after surgery,the MMSE scores in the two groups decreased respectively compared to those 24 hours before surgery.After 6 hours and 24 hours of surgery,the MMSE scores of the study group were higher than those of the control group(6 h after surgery(20.28±1.39)vs(16.77±1.05),t=10.075,P＜0.001;24 h after surgery(22.63±1.52)vs(19.54±1.33),t=7.650,P＜0.001).As for the MMSE score,there was no statistically significant difference between the two groups 24 hours before surgery(P＞0.05),and there was also no significant difference between 24 hours before surgery and 72 hours after surgery either in the study group or in the control group(P＞0.05).Meanwhile,there was no significant difference between the two groups 72 hours after surgery(P＞0.05).The calculation showed no statistically significant difference in the incidence of adverse reactions between the study group and the control group(12.00%(3/25)vs 20.00%(5/25),P＞0.05).Conclusion The application of sevoflurane anesthesia in brain tumor resection can shorten the time of awakening and extubation,reduce brain injury,inhibit inflammatory response and reduce the impact on early cognitive function.Meanwhile,it is of high safety.
SevofluranePropofolBrain tumor resectionSerum NSESerum S100βMini-mental state examination
万方数据
维普
