Analgesic efficacy of parecoxib sodium combined with oxycodone hydrochloride in patients with intertrochanteric fracture of femur
Objective To observe the analgesic efficacy of parecoxib sodium combined with oxycodone hydrochloride in patients with intertrochanteric fracture of femur.Methods Clinical data of 122 patients with intertrochanteric fracture of femur treated in Hangzhou Ninth People's Hospital from January 2020 to March 2024 were retrospectively analyzed.According to different analgesic methods,they were divided into the control group and observation group,with 61 in each group.The patients in the control group received parecoxib sodium for analgesia and those in the observation group parecoxib sodium combined with oxycodone hydrochloride for analgesia.The visual analogue scale(VAS)score and Ramsay sedation scores(RASS)score were compared between the two groups at the 6h,12h and 24h after surgery.Meanwhile,the levels of epinephrine(AD),norepinephrine(NE)and other stress indexes and adverse reactions in both groups 12 h after surgery were determined and compared.Results VAS scores of the observation group were(2.85±0.73)points,(1.89±0.44)points and(0.85±0.19)points at 6h,12h and 24h after surgery,which were lower than those of the control group((3.25±0.23)points,(2.52±0.37)points and(1.58±0.27)points)(t=4.082,8.559,17.269,all P＜0.001).The RASS scores of the observation group were(3.10±0.11)points,(2.79±0.25)points and(2.11±0.24)points at 6h,12h and 24 h after surgery,respectively.They were higher than those of the control group((2.22±0.63)points,(1.86±0.30)points,(1.71±0.14)points)(t=10.747,18.600,11.244,all P＜0.001).At 12h after surgery,AD and NE levels in the observation group were(92.65±6.93)pg.mL-1 and(612.94±10.34)pg.mL-1,respectively,which were lower than those of(100.54±7.23)pg.mL-1 and(644.62±9.52)pg.mL-1 in the control(t=6.153,17.604,both P＜0.001).There was no notable difference in adverse reaction rate between the two groups(4.92%vs 1.64%,χ2=1.034,P＞0.05).Conclusion Parecoxib sodium combined with oxycodone hydrochloride has good analgesic effect in patients with intertrochanteric fracture surgery,and can better improve the pain degree and stress response of patients.The sedation effect is good,and the adverse reactions are less.Therefore,this regimen is relatively safe and reliable.
Intertrochanteric fracture of femurSurgeryParecoxib sodiumOxycodone hydrochlorideAnalgesiaStress responseAdverse reaction
万方数据
维普
