Efficacy of tislelizumab combined with three-dimensional brachytherapy in treatment of patients with locally advanced cervical cancer
Objective To observe the impact of tislelizumab on patients with locally advanced cervical cancer undergoing three-dimensional brachytherapy.Methods A total of 120 patients with locally advanced cervical cancer admitted to Yuncheng Central Hospital from January 2022 to August 2023 were enrolled in this study.The 120 patients were randomly divided into the control group and combination group,with 60 in each group.All the patients in both groups received intensity-modulated radiother-apy and platinum-based monotherapy concurrent chemotherapy.The patients in the control group received pure three-dimensional brachytherapy while those in the combination group received tislelizumab in addition to the three-dimensional brachytherapy.The clinical efficacy,changes in tumor volume,and serum levels of squamous cell carcinoma antigen(SCC)and carcinoembryonic antigen(CEA)were compared between the two groups.Meanwhile,the changes in T lymphocyte subsets(CD4+,CD8+)and the oc-currence of adverse reactions were also compared.Results The disease control rate in the combination group(91.67%,55/60)was significantly higher than that in the control(78.33%,47/60)(χ2=4.183,P＜0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P＞0.05).After treatment,the tumor volume,SCC and CEA were significantly lower in the combination group than in the control((21.65±7.23)cm3 vs(47.23±5.23)cm3),(2.58±0.42)μg·L-1 vs(1.85±0.52)μg·mL-1),(1.85±0.52)μg·mL-1 vs(4.29±0.76)μg·mL-1)(all P＜0.05).Furthermore,the CD4+level was remarkably higher in the combination group than in the control((29.54±3.85)%vs(27.65±4.23)%,P＜0.05),while the CD8+level in the combined treatment group was lower than that of the control((28.11±3.33)%vs(29.65±2.22)%,P＜0.05).Conclusion Tislelizumab can enhance the clinical efficacy of three-dimensional brachytherapy in patients with locally advanced cervical cancer and reduce tumor marker levels.In addition,the treatment-related adverse reactions are tolerable.
万方数据
维普
