Efficacy of budesonide at different dosages in treatment of acute asthma exacerbation in children
Objective To investigate the clinical efficacy of budesonide at different dosages in the treatment of acute asthma exacerbation in children and its effect on changes in eosinophil(EOS)levels.Methods One hundred and three children with acute asthma exacerbation admitted to Datong First People's Hospital from March 2021 to June 2023 were selected as the research subjects and grouped using the random number table method.All children were subjected to the therapy of budesonide combined with montelu-kast sodium.However,budesonide was given at a dosage of 0.5 mg each time in the low-dosage group(n=51)and 1.0 mg each time in the high-dosage group(n=52).Then the clinical efficacy and adverse reactions were observed in both groups.Results No statistical difference was found in clinical efficacy rate between the two groups(90.19%vs 96.15%,χ2=1.442,P＞0.05).An increase in Forced Ex-piratory Volume in First Second(FEV1),peak expiratory flow(PEF),and forced vital capacity(FVC)and a reduction in EOS were found in all patients after treatment,and the high-dosage group showed a larger FEV1((1.87±0.31)L vs(1.46±0.28)L),FVC((3.04±0.69)L vs(2.57±0.62)L)and PEF((3.10±0.38)L·s-1 vs(2.67±0.34)L·s-1),and lower EOS((0.27±0.09)×109·L-1 vs(0.19±0.08)×109·L-1)as com-pared with the low-dosage group,demonstrating statistical difference(t=7.039,6.048,3.634,4.770,all P＜0.05).There was no significant difference in the adverse reaction rate between the two groups(7.84%vs 9.61%,χ2=0.101,P＞0.05).Conclusion Both 0.5 mg and 1.0 mg of budesonide has good efficacy and safety profile in the treatment of acute asthma exacerbation in children.Budesonide admin-stered at a dosage of 1.0 mg each time can exert better effect.
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维普
