Therapeutic effect of Reduning injection combined with azithromycin on pneumonia in children caused by mycoplasma pneumoniae
Objective To investigate the efficacy of Reduning injection combined with azithromycin(AZM)in the treatment of mycoplasma pneumoniae pneumonia(MPP)in children and its effects on serum toll-like receptor 2(TLR2),tumor necrosis factor α-induced protein-8-like molecule 2(TIPE2),soluble programmed death receptor 1(sPD-1)and immune function.Methods A total of 82 children with MPP admitted to Nanjing Tongren Hospital from October 2020 to August 2023 were divided into the control group and the experimental group by the random number table method.The patients in the control group were treated with AZM and those in the experimental group with Reduning injection combined with AZM.One course of treatment lasted for 7 days and the patients in both groups were treated and followed up until discharge.The therapeutic efficacy,recovery status,serum levels of TLR2,TIPE2 and sPD-1 before and after treatment,and the occurrence of adverse reactions during hospitalization were compared between the two groups.Results After treatment,the total effective rate was significantly higher in the experimental group than in the control(75.61%vs 95.12%,χ2=6.248,P＜0.05).The duration of fever,hospitalization,cough in the experimental group were(4.76±0.51)d,(9.78±0.95)d,(7.03±0.67)d,which were shorter than those of(7.22±0.76)d,(12.95±0.82)d,(8.89±0.72)d in the control(t=17.210,16.174,12.109,all P＜0.05).After treatment,TIPE2 level in the experimental group was(57.70±5.91) pg·mL-1,which was higher than that of(42.63±4.23) pg·mL-1 in the control(t=13.277,P＜0.05).The serum levels of CD8+,TLR2,sPD-1 in the experimental group were(24.76±1.52)%,(4.46±0.89) ng·mL-1 and(141.65±26.40) μg·L-1,which were lower than those of(27.2±1.15)%,(7.03±1.34) ng·mL-1,(176.73±38.35) μg·L-1 in the control(t=8.365,10.230,4.825,all P＜0.05).The incidence of adverse reactions during hospitalization was not statistically different between the two groups(19.51%vs 12.20%,χ2=0.823,P＞0.05).Conclusion Reduning injection combined with AZM has good therapeutic effect on MPP in children since it can promote their recovery and regulate the expression levels of TLR2,TIPE2 and sPD-1 in the body.Meanwhile,it is of high safety.
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