Objective To compare oseltamivir with peramivir in treatment of infantile influenza virus pneumonia.Methods A total of 120 children with influenza virus pneumonia admitted to Zhangjiagang Fifth People's Hospital from December 2022 to December 2023 were randomly divided into the observation and control group,with 60 in each group.In addition to routine treatment,the patients in the observation group were given peramivir and those in the control were given oseltamivir.The therapeutic effect,clinical indexes and changes in the immune function indexes(CD4+,CD8+,CD4+/CD8+)and inflammatory factors(interleukin-6(IL-6),CRP,tumor necrosis factor-α(TNF-α))were compared between the two groups.The occurrence of adverse reactions was also compared.Results The total response rate in the observation group was 91.67%(55/60)and that in the control was 85.00%(51/60),demonstrating no significant difference(χ2=1.294,P＞0.05).The drug cost and levels of CD4+and CD4+/CD8+in the observation group were(685.55±125.76)yuan,(38.01±2.76)%and(1.54±0.52),respectively,which were significantly higher than those of(157.85±24.86)yuan,(34.88±2.62)%and(1.32±0.36)in the control.The difference was statistically significant(t=31.886,P＜0.01,t=6.371,P＜0.01,t=2.694,P＜0.01).Body temperature recovery time,cough disappearance time,lung rales disappearance time,hospital stay and the levles of CD8+,TNF-α,CRP,IL-6 were(2.68±0.87)d,(9.01±1.25)d,(6.57±0.75)d,(7.75±1.55)d,(24.76±1.54)%,(6.34±1.57)ng·L-1,(5.18±1.24)mg·L-1 and(11.58±2.04)ng·L-1,respectivley in the observation group.They were significantly shorter than or less than those of(4.78±1.06)d,(11.46±1.57)d,(10.75±1.74)d,(12.76±1.88)d,(26.88±1.65)%,(9.48±2.35)ng·L-1,(6.62±1.64)mg·L-1,(14.03±3.16)ng·L-1 in the control(t=11.862,P＜0.01,t=9.456,P＜0.01,t=17.088,P＜0.01,t=15.927,P＜0.01,t=7.276,P＜0.01,t=8.606,P＜0.01,t=5.425,P＜0.01,t=5.046,P＜0.01).The incidence of adverse reactions was 15.00%(9/60)in the observation group,which was slightly higher than that of 13.33%(8/60)in the control(χ2=0.069,P＞0.05).Conclusion Oseltamivir is comparable to peramivir in the treatment of pediatric influenza virus pneumonia.However,peramivir can shorten the time to symptom improvement and better improve immune function and inflammation levels besides the high cost.
OseltamivirPeramivirInfluenza virus pneumonia in childrenImmune indexInflammatory factorCurative effectAdverse drug reaction
维普
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