Objective To investigate the clinical efficacy and analyze the safety of fluticasone propionate combined with keto-tifen in pediatric allergic asthma.Methods A total of102children with allergic asthma admitted to Hai'an People's Hospital from January 2020 to January 2022 were selected as the study subjects and divided into the control group and trial group according to the randomized numerical table method,with 51 in each group.The patients in the control group were treated with fluticasone propio-nate and those in the trial group with fluticasone propionate combined with ketotifen.The symptomatic improvement,pulmonary function indexes,serologic indexes and the incidence of adverse reactions were compared between the two groups.Results The Childhood Asthma Control Test Scale(C-ACT)scores increased in both groups after treatment,and the trial group's score was higher than the control group's score((23.27±3.29)scoresvs(21.62±2.83)scores,t=2.715,P＜0.05).The first-second expiratory volume with exertion(FEV1),expiratory lung capacity(FVC),and peak expiratory flow(PEF)of the highest expiratory flow rate(PEF)increased in both groups after treatment,and these indexes were(2.16±0.47)L,(1.98±0.34)Land(3.43±1.06)L·s-1 in the trial group,which were higher than those of(1.85±0.54)L,(1.75±0.31)L and(2.92±0.95)L·s-1 in the control(t=3.092,3.259,2.559,all P＜0.05).The serum immunoglobulin E(IgE)and interleukin-6(IL-6)levels were decreased in both groups,and the levels of the 2indicators were(135.62±23.70)μg·L-1 and(7.24±1.41)ng·L-1 in the trial group,which were lower than those of(152.46±22.38)μg·L-1 and(9.73±1.38)ng·L-1 in the control(t=3.689,2.559,both P＜0.05).The incidence of adverse reactions was not significantly different between the two groups(7.84%vs 11.76%,χ2=0.793,P＞0.05).Conclusion Fluticasone propionate combined with ketotifen has a good therapeutic effect on paediatric allergic asthma since it can improve the asthma symptoms and lung function of children and redu-cethe serum levels of IgE and IL-6.Meanwhile,it has a good safety profile.
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