Objective To investigate the effect of oral rivaroxaban combined with urokinase and AngioJet mechanical throm-bectomy on deep vein thrombosis(DVT)after orthopedic surgery.Methods A total of 112 patients with DVT after orthopedic surgery treated in Lishui Central Hospital from January 2021 to April 2023 were retrospectively collected as the research subjects.According to the treatment methods,they were divided into the control group(n=49)and observation group(n=63).The patients in the control group received oral administration of urokinase combined with thrombus suction using AngioJet machine while those in the observation group were treated with rivaroxaban in addition to the regimen in the control group.The clinical efficacy,thigh cir-cumference and calf circumference difference between the affected side and the unaffected side,coagulation indexes and occurrence of adverse reactions were analyzed and compared between the two groups.Results The effective rate of the observation group was higher than that of the control(98.41%vs 87.76%,χ2=0.028,P＜0.05).There was no significant difference in the thigh circumference and calf circumference between the affected side and the unaffected side in both groups before treatment(P＞0.05).After treatment,the difference in the thigh circumference and calf circumference between the affected side and the unaffected side was reduced in both groups and it was significantly higher in the observation group than in the control((3.81±1.00)cm vs(3.13±0.96)cm,(2.46±0.51)cm vs(1.57±0.42)cm,t=3.633,9.882,both P＜0.05).There was no significant difference in coagulation indexes between the two groups before treatment(P＞0.05).After treatment,APTT,TT and PT were shortened in both groups,and FIB expression levels were decreased.In terms of difference,the observation group was higher than the control((17.34±1.97)s vs(8.15±1.67)s,(8.09±1.04)s vs(3.92±1.36)s,(8.80±0.99)s vs(5.72±0.87)s,(2.88±0.88)g·L-1 vs(2.12±0.97)g·L-1,t=26.149,18.393,17.211,4.335,all P＜0.05).No significant difference was found in the incidence of adverse reactions between the two groups(30.16%vs 28.57%,χ2=0.033,P＞0.05).Conclusion Urokinase combined with AngioJet mechanical thrombectomy and oral administration of rivaroxaban can promote the efficacy in treatment of DVT after orthopedic surgery,decrease difference in thigh circumference and calf circumference between the affected side and the unaffected side and improve the coagulation condition.Furthermore,it has a certain degree of safety.
UrokinaseAngioJet mechanical thrombectomyRivaroxabanDeep vein thrombosisCoagulation function
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