Objective To explore the effects of oral loxoprofen sodium tablets combined with dexamethasone injection at different administration times on postoperative pain in patients undergoing impacted tooth extraction.Methods A total of 104 patients undergoing extraction of impacted mandibular teeth in Suining Central Hospital from January 2021 to October 2023 were enrolled in this study and divided into three groups according to the random number table method.In group A(n=35),loxoprofen sodium was taken orally 30 minutes before surgery.In group B(n=34),local injection of dexamethasone 4 mg 30 minutes before surgery+oral administration of loxoprofen sodium tablets 60 mg 30 minutes before surgery was conducted.In group C(n=35),local injection of 4 mg of loxoprofen sodium tablets 30 minutes before surgery and injection of dexamethasone 4 mg+oral administration of loxoprofen sodium tablets 60 mg 3 h after surgery was exerted.The patient's pain level at 30 min,2,4,6,12,and 24 h after surgery was evaluated using a numerical rating scale(NRS)and recorded.Results At 30 minutes after surgery,the NRS scores of group A,group B and group C were(0.39±0.15)points,(0.26±0.19)points,(0.31±0.12)points,respectively,and there was no statistically significant difference in NRS scores among the three groups(P＞0.05).At 2 h after surgery,the NRS scores of group B and group C were lower than those of group A((0.41±0.26)points,(0.65±0.22)points vs(0.96±0.59)points,all P＜0.05).However,there was no statistically significant difference between Group C and Group B(t=0.691,0.740,both P＞0.05).At 6 h after surgery,the NRS scores of group B were lower than those of group A and group C,and the difference was statistically significant((1.03±0.22)points vs(1.96±0.73)points,(1.45±0.58)points,t=1.262,1.578,both P＜0.05).The total amount of emergency analgesic drugs added after surgery in group A,group B and group C was(1.5±0.6)pills,(0.7±0.2)pills and(1.4±0.6)pills,respectively.The number of patients in group B who added emergency analgesic drugs within 24 h after surgery was lower than that in group A and group C,and the difference was statistically significant(t=1.267,1.498,P＜0.05).There were 2 cases of dizziness in group B and 1 case of numbness in the lower lip in Group C after surgery,showing no significant difference between the two groups(5.88%vs 2.86%,χ2=1.427,P=0.275).No adverse reactions such as difficulty in opening mouth,wound infection,bleeding or delayed wound healing occurred in all the three groups.Conclusion Dexamethasone combined with oral loxoprofen 30 minutes before surgery has a better analgesic effect on patients undergoing impacted tooth extraction since it can effectively prolong postoperative analgesia time and has fewer complications.Therefore,this is a safe and effective analgesic method.
DexamethasoneLoxoprofenExtraction of impacted wisdom teethAnalgesiaAdverse drug reaction
万方数据
维普
