Objective To analyze curative efficacy of methylprednisolone sodium succinate injection combined with batroxo-bin injection in treating sudden deafness.Methods According to odd-even picking method,90 patients with sudden deafness ad-mitted to Jinhua Maternal and Child Health Hospital from June 2022 to June 2023 were enrolled in this study and divided into the control group(n=45,treated with methylprednisolone sodium succinate injection)and observation group(n=45,treated with methyl-prednisolone sodium succinate injection combined with batroxobin injection).After 2 weeks of treatment,curative efficacy and ad-verse reactions were compared between the two groups.Results The response rate of treatment was higher in the observation group than in the control(95.56%vs 73.33%),and the difference was statistically significant(χ2=8.459,P＜0.05).After treatment,pure tone average value,auditory evoked potential and auditory brainstem response time in the observation group were significantly lower than those in the control((32.46±4.11)dB vs(37.15±4.68)dB,(51.28±5.49)dB vs(59.64±6.05)dB,(3.55±1.24)ms vs(5.03±1.86)ms,P＜0.05).The levels of plasma viscosity and fibrinogen(FIB)in the observation group were remarkably lower than those in the control((1.28±0.16)mPa·s-1 vs(1.61±0.22)mPa·s-1,(2.54±1.05)g·L-1 vs(3.07±1.10)g·L-1,P＜0.05).The levels of endothelin-1,soluble vascular cell adhesion molecule-1,homocysteine,interleukin-6,interleukin-10 and C-reactive protein in the observation group were also signifi-cantly lower than those in the control((1.34±0.11)pg·mL-1 vs(1.78±0.23)pg·mL-1,(216.25±45.15)μg·L-1 vs(267.28±51.42)μg·L-1,(8.18±2.56)μmol·L-1 vs(11.65±2.35)μmol·L-1,(15.58±2.24)pg·mL-1 vs(19.54±3.12)pg·mL-1,(6.58±1.54)pg·L-1 vs(9.24±1.87)pg·L-1,(7.71±1.20)mg·L-1 vs(9.85±1.37)mg·L-1,P＜0.05).The difference in the incidence of adverse reactions was not statistically signif-icant between the two groups(χ2=2.195,P=0.138).Conclusion Methylprednisolone sodium succinate combined with batroxobin can effectively improve hemorheology and vascular endothelial function,reduce inflammatory response and thus recover hearing lev-el in patients with sudden deafness.Meanwhile,it has significant curative efficacy for this disease.
维普
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