Objective To investigate the efficacy and safety of Guiqi Mixture combined with pegylated recombinant hu-man granulocyte colony-stimulating factor(PEG-rhG-CSF)in preventing myelosuppression after neoadjuvant chemotherapy with docetaxel+epirubicin+cyclophosphamide(TEC)for breast cancer.Methods The clinical data of 92 patients with breast cancer who received TEC neoadjuvant chemotherapy in Taihe Hospital Affiliated to Wannan Medical College from May 2021 to May 2024 was retrospectivley analyzed.The 92 patients were equally randomized into the observation group and control group.The patients in the control group were given PEG-rhG-CSF treatment after 48 h of chemotherapy,and those in the observation group were treated with the combination of Guiqi Mixture on the basis of the regimen in the control group.Bone marrow suppression,white blood cell count(WBC),neutrophil count(NEU),KPS score,TCM symptom score and adverse reactions were compared between the two groups.Results There were 6 cases of bone marrow suppression in gradeⅠ,3 cases of gradeⅡand 2 cases of grade Ⅲ in the observation group,with a total of 11 cases(23.91%).There were 16 cases of bone marrow suppression in grade I,13 cases of gradeⅡ,6 cases of grade Ⅲ and 1 case of grade IV in the control group,with a total of 36 cases(78.26%).The incidence of bone marrow suppression was remarkably lower in the observation group than in the control(χ2=27.187,P＜0.05).After treatment,white blood cell counts and neutrophil counts in the observation group were(7.26±1.59)×109·L-1 and(5.07±0.92)×109·L-1,which were higher than those of(6.23±1.48)×109·L-1 and(4.63±0.87)×109·L-1 in the control(t=3.216,2.356,both P＜0.05).The KPS scores and traditional Chinese medicine symptom scores in the observation group were(95.23±2.47)and(14.23±1.26),which were higher than those of(84.12±2.48)and(17.35±1.24)in the control(t=21.528,11.970,both P＜0.05).The incidence of adverse reactions was not significant-ly different between the two groups(30.43%(14/46)vs 36.96%(17/46),χ2=0.437,P＞0.05).Conclusion Guiqi Mixture combined with PEG-rhG-CSF can effectively improve bone marrow suppression after TEC neoadjuvant chemotherapy for breast cancer,in-crease KPS score and reduce symptom score.Meanwhile,it is of high safety.
Breast cancerGuiqi MixturePegylated recombinant human granulocyte colony-stimulating factorAdjuvant che-motherapyBone marrow suppression
维普
万方数据
