Objective To construct and characterize a lamellar liquid crystal formulation of metformin and investigate its topical efficacy in treating radiation dermatitis.Methods The metformin lamellar liquid crystal was prepared using glycerol monooleate,ethanol and water as matrix materials through the injection method.Physical characterization was conducted using polarizing mirrors and small angle X-ray diffraction.The in vitro transdermal behavior of the formulation was investigated using Franz diffusion cell tech-nology.Additionally,a mouse model of radiation dermatitis was established to evaluate the therapeutic effect of the formulation based on the degree of skin damage.Results The lamellar liquid crystal of metformin exhibited a birefringence phenomenon.Meanwhile,its small angle X-ray scattering peak corresponded to a scattering vector ratio of 3:4,being in consistent with the traditional lamellar liquid crystal space group.Drug releasing from the liquid crystal mainly occurred through diffusion.The 5-hour in vitro transdermal dose of the metformin lamellar liquid crystal group((2 190±182)μg·cm-2)was significantly higher than that of the metformin solution group((979±126)μg·cm-2).Furthermore,the metformin lamellar liquid crystal significantly accelerated wound healing in irradiated mice.Conclusion This study successfully prepared metformin layered liquid crystals with efficient skin penetration properties,which has significant potential for application in the prevention and management of radiation-induced diseases.
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