首页|中国沉香挥发油的化学成分与抗耐甲氧西林金葡菌活性

中国沉香挥发油的化学成分与抗耐甲氧西林金葡菌活性

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分析中国沉香的挥发油成分,并测试其抗耐甲氧西林金葡菌活性.采用水蒸气蒸馏法提取中国沉香挥发油进行GC/MS分析,峰面积归一化法计算各成分相对含量,采用NIST05和WILEY275L数据库匹配,以及将质谱图与文献数据进行对照的方法进行鉴定.采用滤纸片琼脂扩散法测试挥发油抗菌活性.挥发油对耐甲氧西林金葡菌显示强活性.共检测到66个色谱峰,其中30个化合物得到鉴定,占挥发油总量的59.80%.26个化合物被鉴定为倍半萜类化合物,占挥发油总量的54.26%.B.沉香呋喃(8.96%),枯苏醇(7.82%),(-)-jinkh-eremol(5.04%),沉香螺旋醇(4.53%),白木香呋喃酸(4.09%)为主要的倍半萜.4个降倍半萜和其他一些倍半萜,如10-表-γ-桉叶油醇,α-沉香呋喃,epi-ligulyl oxide等为首次从中国沉香中检出.本文首次报道了中国沉香挥发油对耐甲氧西林金葡菌具有抗菌活性.
Chemical composition and anti-MRSA activity of the essential oil from Chinese eaglewood
To analyze the constituents of essential oil from Chinese eaglewood [resinous wood of Aquilaria sinensis (Lout.)Gilg]and its anti-methicillin-resistant Staphylococcus aureus (MRSA) activity. The essential oil was extracted by water-steam distillation and analyzed by GC/MS method. The relative contents of the compounds were determined by normalization. The compounds were characterized by NIST05 and WlLEY275L database matching and comparison of their MS spectra with those of literature data. Antibacterial activity of the oil was assayed by the filter paper disc agar diffusion method. The oil showed sig-nificant antibacterial activity against MRSA. Sixty-six chromatographic peaks were detected, among them thirty compounds com-prising 59.80% of the total essential oil were characterized. Twenty-six compounds comprising 54.26% of the oil were identified as sesquiterpenes.β-Agarofuran (8.96%), kusunol (7.82%), (-)-jinkoh-eremol (5.04%), agarospirol (4.53%), baimuxifuranic acid (4.09%) were the major sesquiterpenes. Four nor-sesquiterpenes and some other sesquiterpenes, such as 10-epi-γ-eudesmol, α-agarofuran,epi-ligulyl oxide, etc. were detected in Chinese eaglewood oil for the first time. This is the first report about anti-MRSA activity of Chinese eaglewood oil from A. sinensis.

Chinese eaglewoodAquilaria sinensis Lout. GilgEssential oilGC/MSAntibacterial activityMRSA

梅文莉、曾艳波、吴娇、崔海滨、戴好富

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中国热带农业科学院,热带生物技术研究所,海南,海口,571101

中国沉香 白木香 挥发油 气相色谱.质谱 抗菌活性 耐甲氧西林金葡菌

国家重点基础研究发展计划(973计划)Science and Technology Foundation of Chinese Academy of Tropical Agricultural SciencesNational Nunprofi Institute Research Grant of CATAS-ITBB

2007CB116306RKY0726ITBBZDO743

2008

中国药学(英文版)
中国药学会

中国药学(英文版)

影响因子：0.534
ISSN：1003-1057
年,卷(期)：2008.17(3)
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