Advancements in anti-tuberculosis drug potentiators:targeting mechanisms of tuberculosis resistance
Tuberculosis(TB)constitutes a formidable global health challenge,exacerbated by the rise of multidrug-resistant TB(MDR-TB)strains.The effectiveness of anti-TB drugs has been hindered by this emergence of resistance.To address this,the development of synergistic compounds,informed by drug resistance mechanisms,holds promise for mitigating resistance emergence and shortening treatment durations.This review focuses on the amalgamation of anti-TB drugs with potentiators targeting the cell wall,efflux pump,and β-lactamase.Our aim is to offer insights that guide the future development of novel potentiators with enhanced efficacy and reduced toxicity.
TuberculosisDrug-resistant strainsAnti-tuberculosis drug potentiators
杨建慧、王潇、张金波、刘忆霜
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佳木斯大学基础医学院,黑龙江佳木斯 154007
中国医学科学院北京协和医学院医药生物技术研究所,国家新药(微生物)筛选实验室,北京 100050
结核病 耐药菌株 抗结核药物增效剂
Chinese Academy of Medical Sciences(CAMS)Innovation Fund for Medical Sciences国家自然科学基金
万方数据
维普
