首页|Exploring the impact of tacrolimus on kidney transplant recipients:insights into immunological outcomes
Exploring the impact of tacrolimus on kidney transplant recipients:insights into immunological outcomes
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To minimize graft rejection,it is crucial to reduce immunosuppression.In the present study,we investigated immunological markers in the blood of transplant patients who did not receive tacrolimus.We also assessed alloreactive CD4+CD25+FoxP3+Tregs both before transplantation and after tacrolimus reduction.The comparative analysis included 50 individuals experiencing early rejection after tacrolimus discontinuation and 100 non-rejectors.Before reducing tacrolimus,rejectors exhibited elevated levels of memory CD8+T cells compared to Tregs,while non-rejectors displayed a lower ratio of memory CD4+T cells to Tregs.Following tacrolimus removal,rejectors showed an increase in naïve T cells and a decrease in effector T cells.After transplantation,CD4+Treg levels declined,but their anti-donor regulatory function remained consistent in both rejectors and non-rejectors.Immunological correlation revealed an association between acute rejection after tacrolimus discontinuation and the pre-reduction ratio of memory T cells to regulatory T cells.These indicators identified individuals whose immunosuppression could be safely reduced.
TacrolimusKidneyTransplantImmune systemRejection
Zainab A Abbood、Ahmed Hamza AL-Shammari、Eman M.Jasim、Amjad I.Oraibi
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Department of Pharmacy,Kut University College,Alkut,Wasit,Iraq,52001
AL-Manara College For Medical Science/Department of Pharmacy,Misan,Iraq,62001
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