蛇毒解离素通过阻止与整合素的结合,抑制细胞-细胞、细胞-基质相互作用和信号转导,可能成为多种疾病的先导治疗药物.本研究旨在对近年来蛇毒解离素的研究热点进行文献计量学分析.本文使用相关关键词检索Web of Science Core Collection(WOSCC)数据库,使用CiteSpace和VOSviewer进行分析.我们纳入了2009年至2023年间发表的142篇文献,这些文献由来自42个国家207个研究所的670位作者发表在74种期刊上.美国发表最多篇,得克萨斯农工大学是发表最多论文的组织.Elda E.Sanchez是主要作者,《毒素》是发表论文最多的杂志.关键词分析表明,该领域的研究趋势主要集中在表达、体外和含ASP肽方面.本研究为2009-2023年全球蛇毒解离素的研究提供了有价值的分析,并为未来的研究方向提供了参考.本研究揭示了当前解离素的研究热点,这些结果可以为进一步的研究提供重要的方向.
Bibliometric and visual analysis of global research on snake venom disintegrins(2009-2023)
Snake venom disintegrins,through their inhibition of integrin-related binding,effectively impede both cell-cell and cell-matrix interactions as well as signal transduction pathways,rendering them promising candidates for lead therapeutics across a spectrum of diseases.This study aimed to conduct a comprehensive bibliometric analysis,elucidating recent trends in disintegrin research.Using relevant keywords,we meticulously explored the Web of Science Core Collection(WOSCC)database.Employing CiteSpace and VOSviewer,we conducted an exhaustive analysis,encompassing 142 documents published between 2009 and 2023.These publications,dispersed across 74 journals,involved 670 authors representing 207 institutes spanning 42 countries.Notably,the United States contributed the highest number of records,with Texas A&M University emerging as the most prolific institution.Within this landscape,Elda E.Sanchez emerged as the foremost author,and Toxicon emerged as the predominant journal.Keyword analysis underscored prevailing research foci,with an emphasis on expression,in vitro experimentation,and ASP-containing peptides.This study presented a comprehensive overview of disintegrin research globally,spanning the period from 2009 to 2023,and held potential utility in guiding future research endeavors.By identifying current research hotspots,our findings offered invaluable insights to shape forthcoming investigations in this dynamic field.
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