Research Progress in the Relationship Between Neurofilament Light Chain Protein and Cognitive Impairment in Type 2 Diabetes Mellitus
Metabolic abnormality in type 2 diabetes mellitus(T2DM)can cause damage to the central nervous system,leading to cognitive decline.Neurofilament light chain protein(NFL),as a blood marker of neuroaxonal injuries,is significantly associated with the onset of cognitive impairment and affected by the renal function.It can participate in the development of cognitive impairment in T2DM through inflammation,blood-brain barrier breakdown,interaction between microglia and neurons,and Tau protein phosphorylation.We re-viewed the mechanism of the occurrence and development of NFL-involved cognitive impairment and the correla-tion between NFL and renal function in T2DM,hoping to provide a basis for early diagnosis and treatment of cog-nitive impairment in T2DM patients.
type 2 diabetes mellituscognitive impairmentneurofilament light chain protein
万方数据
维普
