多巴胺与发作性睡病临床病征学的相关性研究进展
Research Progress in the Correlation Between Dopamine and Clinical Characterization of Narcolepsy
赵婉玉 1唐吉友1
作者信息
- 1. 山东第一医科大学第一附属医院神经内科, 济南 250014
- 折叠
摘要
多巴胺是一种神经递质,广泛存在于哺乳动物和人类的体液、血液及尿液中,负责其功能和新陈代谢的调节,多巴胺系统参与了动物和人类发作性睡病的神经生物学机制,但当实际检测发作性睡病患者脑脊液中多巴胺水平时,却得出了不同甚至相反的结论.已有研究证实发作性睡病产生的机制与促食欲素不可逆丢失有关,环境因素与遗传因素相互作用引起的自身免疫反应使下丘脑促食欲素神经元被破坏,促食欲素分泌减少,因此患者觉醒水平降低.本文通过分析1982 年至2023 年收集的40 余篇文献来阐述多巴胺与发作性睡病临床表征学的研究进展及现状,为研究多巴胺水平与发作性睡病临床表征学的关系及寻找2 型发作性睡病的生物标志物提供一定参考.
Abstract
Dopamine,a neurotransmitter ubiquitous in the body fluids,blood,and urine of mammals and humans,is responsible for regulating their functions and metabolism.The dopamine system is involved in the neurobiological mechanisms of narcolepsy in animals and humans.However,researchers have drawn different or even opposite conclusions when measuring the dopamine level in the cerebrospinal fluid of narcolepsy pa-tients.Studies have confirmed that the occurrence of narcolepsy is related to the irreversible loss of orexins.The autoimmune reaction caused by the interactions of environmental factors with genetic factors destroys the hypotha-lamic orexin neurons and reduces orexin secretion,thereby lowering the level of arousal.We introduce the re-search progress and current status of dopamine and clinical characterization of narcolepsy by reviewing more than 40 articles published from 1982 to 2023,aiming to provide a reference for studying the relationship between the dopamine level and clinical characterization of narcolepsy and searching for the biomarkers of type 2 narcolepsy.
关键词
多巴胺/发作性睡病/猝倒/觉醒/幻觉Key words
dopamine/narcolepsy/cataplexy/arousal/hallucination引用本文复制引用
基金项目
国家自然科学基金(81471345)
山东省自然科学基金(ZR2020MH160)
出版年
2024
国家科技期刊平台
NSTL
万方数据