Endosomal Sorting Complex Required for Transport:The Molecular Machine for Ensuring Proper Mitosis
Mitosis is a key step of eukaryote proliferation.Endosomal sorting complex required for trans-port,a protein complex closely associated with membrane shearing,is involved in endosome maturation,virus budding,and autophagy.The structural and functional abnormalities of the complex are associated with the occur-rence and progression of cancer and other diseases.In this paper,we summarized the roles of the endosomal sor-ting complex required for transport in different stages of mitosis and reviewed the studies about the role of the com-plex in regulating mitosis in diseases.
mitosisendosomal sorting complex required for transportspindle assembly checkpointcancer
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