中国医学前沿杂志(电子版)2024,Vol.16Issue(1) :8-12.DOI:10.12037/YXQY.2024.01-02

粪菌移植临床应用规范及前景

Clinical applicable standards and prospects of fecal microbiota transplantation

马磊 邢卉春
中国医学前沿杂志(电子版)2024,Vol.16Issue(1) :8-12.DOI:10.12037/YXQY.2024.01-02

粪菌移植临床应用规范及前景

Clinical applicable standards and prospects of fecal microbiota transplantation

马磊 1邢卉春1
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作者信息

  • 1. 首都医科大学附属北京地坛医院肝病三科,北京 100015
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摘要

肠道菌群失调已经被证明与多个系统的疾病的发生密切相关.粪菌移植作为近年来出现的新的治疗模式,可以改善受者肠道菌群组成,并取得良好的临床效益,展现出了巨大的治疗潜力.除了被纳入复发性艰难梭菌感染的诊疗指南,粪菌移植还被应用于许多其他疾病的临床研究.多个国家和地区相继出台指南或专家共识规范粪菌移植在临床实践和研究中的应用.本文将对粪菌移植的临床应用规范和未来展望进行述评.

Abstract

Intestinal microbiota dysbiosis has been demonstrated to be closely associated with the onset of various systemic diseases.Fecal microbiota transplantation(FMT),as a new treatment mode emerging in recent years,has achieved favorable clinical outcomes by improving the composition of the recipient's intestinal microbiota,thereby showing significant therapeutic potential.In FMT has been recommended by guidelines for recurrent Clostridioides difficile infection,and it also be applied to many clinical studies for other diseases.Several countries and regions have published guidelines or expert consensus to standardize the application of FMT in clinical practice and research.This review will discuss the clinical applicable standards of FMT and provide insights into future prospects.

关键词

粪菌移植/肠道微生态/临床应用

Key words

Fecal microbiota transplantation/Intestinal microbiota/Clinical application standards

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基金项目

国家重点研发计划(2022YFC2304500)

国家重点研发计划(2021YFC2301801)

北京市科技重大项目(20220383ky)

首都卫生发展科研专项(首发2020-1-2171)

北京市医院管理中心消化内科学科协同发展中心项目(XXT26)

出版年

2024
中国医学前沿杂志(电子版)
人民卫生出版社有限公司

中国医学前沿杂志(电子版)

CSTPCDCSCD北大核心
影响因子:1.088
ISSN:1674-7372
参考文献量31
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