Correlation between cumulative exposure to high sensitivity C-reactive protein and carotid intima media thickness
王雅婷 1刘晓娜 1吴寿岭 2刘雪梅1
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作者信息
1. 首都医科大学附属北京中医医院超声科,北京 100010
2. 开滦总医院心内科,河北 唐山 063000
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摘要
目的 探讨累积高敏C反应蛋白(cumulative high sensitivity C-reactive protein,cumCRP)与颈动脉内膜中层厚度(carotid intima media thickness,CIMT)的相关性.方法 本研究回顾性对连续参加了 2006-2007年、2008-2009年、2010-2011年、2012-2013年4次健康体检并完成颈动脉超声的开滦职工4 701例进行横断面分析.观察对象年龄(50.9± 10.9)岁,其中男性2 510例(53.39％).根据暴露剂量与暴露时间乘积之和计算出4次健康体检的cumCRP并根据其三分位数将观察对象分为Q1、Q2、Q3 三组,分析cumCRP对CIMT的影响.结果 随着cumCRP增加,CIMT逐渐增厚(P＜0.000 1).多因素Logistic回归分析校正其他混杂因素后,以Q1组作对照,Q2、Q3组的OR值分别为1.36(95％CI:1.01～1.82)、1.49(95％CI:1.07～2.07).结论cumCRP是CIMT增厚的独立危险因素;不同性别及年龄均要重视 cumCRP.
Abstract
Objective To investigate the correlation between cumulative high sensitivity C-reactive protein(cumCRP)and carotid intima media thickness(CIMT).Methods A retrospective cross-sectional analysis was performed on 4701 employees who participated four health examinations in 2006-2007,2008-2009,2010-2011,2012-2013 and complete the carotid ultrasound were enrolled.The mean age of the observation subjects was(50.9±10.9)years old,and 2 510(53.39％)of them were males.The cumCRP of four health examinations was calculated according to the sum of the product of exposure dose and exposure time,and the observation subjects were divided into three groups according to the cumCRP quartile.The impact of cumCRP on CIMT was analyzed.Results With the increase of cumCRP,CIMT thickness showed increased.(P＜0.000 1).Multivariate logistic regression analysis after adjustment showed that compared with the quartile 1 group,the OR(95％CI)for CIMT in quartile 2 and quartile 3 group were 1.36(1.01-1.82)and 1.49(1.07-2.07)respectively.Conclusion CumCRP may be an independent risk factor for CIMT thickness.Different sexes and ages should pay attention to cumCRP.
关键词
累积高敏C反应蛋白/颈动脉内膜中层厚度/相关性/危险因素
Key words
Cumulative high sensitivity C-reactive protein/Carotid intima-media thickness/Correlation/Risk factor
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