中国医学前沿杂志(电子版)2024,Vol.16Issue(1) :84-91.DOI:10.12037/YXQY.2024.01-14

基因位点检测在老年常见复杂疾病风险评估及个体化干预中的应用

Application of gene locus detection for risk assessment and individualized intervention of common complex diseases in the elderly

和昱辰 刘家云
中国医学前沿杂志(电子版)2024,Vol.16Issue(1) :84-91.DOI:10.12037/YXQY.2024.01-14

基因位点检测在老年常见复杂疾病风险评估及个体化干预中的应用

Application of gene locus detection for risk assessment and individualized intervention of common complex diseases in the elderly

和昱辰 1刘家云1
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作者信息

  • 1. 空军军医大学第一附属西京医院检验科;陕西西安 710032
  • 折叠

摘要

在步入老龄化社会的今天,早期筛查和诊断老年人常见的复杂疾病变得愈发重要.因此,本文旨在总结临床上与老年常见复杂疾病相关的几种常见基因位点检测项目,例如血栓高危风险评估、脑卒中风险评估、痴呆风险评估和2型糖尿病风险评估,并以氯吡格雷、阿司匹林、华法林及二甲双胍为例,针对不同基因型提出了个体化用药方案及相应的用药建议.最后,我们还列举了常见的个体化用药基因位点检测方法.通过本文的介绍,希望能为老年常见复杂疾病的早期发现和个体化干预提供参考依据.

Abstract

Wtih a rapidly increase of aging population,early detection and diagnosis of common age-related complex diseases become more important.As such,this review aims to comprehensively summarize several gene loci testing projects that are commonly utilized in clinical settings for assessing high-risk thrombosis,stroke,dementia,and type 2 diabetes in elderly patients.Furthermore,we propose individualized medication plans and corresponding drug recommendations based upon diverse genotypes,taking clopidogrel aspirin,walfarin and metformin as examples.Ultimately,this article is helpful to provide references and tools to effectively screen,treat,and manage elderly patients with complex diseases.

关键词

老年人/常见复杂疾病/基因位点检测/疾病风险评估/个体化干预

Key words

The elderly/Common complex diseases/Gene locus detection/Disease risk assessment/Individualized inter-vention

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出版年

2024
中国医学前沿杂志(电子版)
人民卫生出版社有限公司

中国医学前沿杂志(电子版)

CSTPCDCSCD北大核心
影响因子:1.088
ISSN:1674-7372
参考文献量28
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