Ryanodine receptor 2(RyR2)is an important calcium ion release channel in the sarcoplasmic reticulum of myocardial cells,which plays a crucial role in modulating the cardiac contractility and relaxation.In the recent years,more and more studies have reported that mutations in the RYR2 gene encoding RyR2 protein can lead to various types of inherited cardiac arrhythmias,including catecholaminergic polymorphic ventricular tachycardia(CPVT),long QT syndrome(LQTS),idiopathic ventricular fibrillation(IVF)and atrial fibrillation(AF).This review aims to summarize the functional abnormalities of RyR2 ion channel caused by RYR2 gene mutations and their associations with various types of inherited arrhythmias.A comprehensive understanding of RyR2 related inherited arrhythmias will be beneficial for exploring a new idea for clinical diagnosis and treatment of hereditary heart diseases.
维普
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