The effect of sodium-dependent glucose transporters 2 inhibitors on coronary microvascular dysfunction in heart failure with preserved ejection fraction
The effect of sodium-dependent glucose transporters 2 inhibitors on coronary microvascular dysfunction in heart failure with preserved ejection fraction
Heart failure with preserved ejection fraction(HFpEF)accounts for approximately 50%of heart failure and shows an increasing trend.The pathogenesis of HFpEF is still not fully understood,and there is a lack of effective clinical treatment.Recent research evidence suggests that coronary microvascular dysfunction plays a crucial role in the occurrence and development of HFpEF.Numerous clinical trials have confirmed that sodium-dependent glucose transporters 2(SGLT2)inhibitors significantly improve the clinical prognosis of heart failure with reduced ejection fraction(HFrEF)patients and are independent of blood glucose control.They have been recommended as the basic treatment for HFrEF patients.SGLT2 inhibitors have a wide range of biological functions.Studies have confirmed that SGLT2 inhibitors can improve coronary microvascular function by inhibiting inflammation and oxidative stress,reducing insulin resistance,and maintaining endothelial function.At present,SGLT2 inhibitors are considered to be the ideal regimen for the treatment of HFpEF,although sufficient evidence-based medical evidence is still lacking.
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