中国医学前沿杂志(电子版)2024,Vol.16Issue(4) :前插1,1-7.DOI:10.12037/YXQY.2024.04-01

妊娠期糖尿病对母亲及其子代近远期健康的影响

Effects of gestational diabetes mellitus on the short and long term health of mothers and their offspring

隽娟 高迪 杨慧霞
中国医学前沿杂志(电子版)2024,Vol.16Issue(4) :前插1,1-7.DOI:10.12037/YXQY.2024.04-01

妊娠期糖尿病对母亲及其子代近远期健康的影响

Effects of gestational diabetes mellitus on the short and long term health of mothers and their offspring

隽娟 1高迪 1杨慧霞1
扫码查看

作者信息

  • 1. 北京大学第一医院 妇产生殖医学中心,北京 100034
  • 折叠

摘要

妊娠期糖尿病(gestational diabetes mellitus,GDM)严重影响母亲及其子代近远期健康.GDM会增加剖宫产、巨大胎儿、大于胎龄儿、新生儿低血糖、高胰岛素血症、高胆红素血症、新生儿呼吸窘迫综合征、早产、肩难产、产伤等不良围产儿结局的发生风险;对于远期健康的影响来看,GDM会导致母亲及其子代成年期2型糖尿病(type 2 diabetes mellitus,T2DM)、心血管疾病(cardiovascular disease,CVD)等慢性非传染性疾病的风险显著增加.本文从GDM对母儿不良妊娠结局的影响,GDM对母亲T2DM、CVD远期健康的影响,GDM对子代肥胖、糖代谢异常、CVD、神经系统发育的影响三方面,基于最新的循证医学证据进行了阐述,强调了应关注生命早期1000 d,充分认识到生命早期对于预防远期慢性非传染性疾病的重要性,针对GDM母亲及其子代应尽早采取均衡饮食、积极锻炼等个性化预防和干预措施,对于降低近期不良妊娠结局和远期慢性非传染性疾病的风险和全生命周期健康具有十分重要且深远的意义.

Abstract

Gestational diabetes mellitus(GDM)seriously affects the short and long-term health of mothers and their offspring.GDM increases the risk of adverse perinatal outcomes such as cesarean section,macrosomia,neonatal hypoglycemia,hyperinsulinemia,hyperbilirubinemia,neonatal respiratory distress syndrome,premature birth,shoulder dystocia,and birth injuries in offspring;In terms of long-term health impact,GDM will significantly increase the risk of non-communicable chronic diseases such as type 2 diabetes(T2DM)and cardiovascular disease(CVD)in the adult period of both mothers and their offspring.This article elaborates the impact of GDM on adverse pregnancy outcomes in both mother and fetus,the impact of GDM on the long-term health of mothers the impact of GDM on offspring obesity,abnormal glucose metabolism,CVD,and neurological development based on the latest evidence-based medicine evidence.It was emphasized that attention should be paid to the early life 1000 day,and the importance of early life in preventing long-term non-communicable chronic diseases should be fully recognized.For GDM mothers and their offspring,personalized prevention and intervention measures such as balanced diet and active exercise should be taken as soon as possible.It has significant and far-reaching implications for reducing the risk of adverse pregnancy outcomes and long-term non-communicable chronic diseases,as well as for overall lifecycle health.

关键词

妊娠期糖尿病/近远期健康影响/母亲/子代

Key words

Gestational diabetes mellitus/Short and long-term health impacts/Mother/Offspring

引用本文复制引用

基金项目

国家自然科学基金(82003528)

中央高水平医院临床研究基金(22cz020401-4811009)

国家重点研发计划(2021YFC2700700)

出版年

2024
中国医学前沿杂志(电子版)
人民卫生出版社有限公司

中国医学前沿杂志(电子版)

CSTPCD北大核心
影响因子:1.088
ISSN:1674-7372
被引量1
参考文献量44
段落导航相关论文