The impact of hypertensive disorders of pregnancy on the long-term health of mother and offspring
高迪 1隽娟 1杨慧霞1
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作者信息
1. 北京大学第一医院 妇产生殖医学中心,北京 100034
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摘要
妊娠期高血压疾病(hypertensive disorders of pregnancy,HDP)是一类严重的产科常见并发症,包括妊娠期高血压(gestational hypertension,GH)和子痫前期-子痫(preeclampsia-eclampsia,PE-E)等.近年来,国内外大量研究提示,GH/PE不仅会增加孕产妇及胎儿的不良结局发生风险,同时可能会对母亲及其子代的远期健康产生影响,本文将重点阐述GH/PE对母儿远期健康影响的相关研究进展,从远期慢性高血压、糖尿病及血脂异常、心血管疾病、动脉粥样硬化和心脏功能、肾脏疾病、神经系统疾病、远期死亡风险的角度阐述对母亲远期健康的影响,同时从子代远期心血管代谢风险、神经系统发育、过敏性疾病及死亡风险等角度阐述对子代远期健康的影响.
Abstract
Hypertensive disorders of pregnancy(HDP)are a group of severe common obstetric complications,including gestational hypertension(GH)and preeclampsia-eclampsia(PE-E).In recent years,numerous studies have suggested that GH/PE not only increases the risk of adverse outcomes for pregnant women and their fetuses,but may also impact the long-term health of both mothers and offspring.This article will focus on the research progress regarding the impact of GH/PE on the long-term health of mothers and offspring.It will discuss the long-term effects on maternal health from the perspectives of chronic hypertension,diabetes,dyslipidemia,cardiovascular diseases,atherosclerosis,cardiac function,renal diseases,neurological disorders,and the risk of long-term mortality.Additionally,it may also lead to increased long-term risks of cardiovascular health,neurodevelopment,allergic diseases,and even heightened overall mortality risk in offspring.
关键词
妊娠期高血压疾病/妇幼健康/远期影响
Key words
Hypertensive disorders of pregnancy/Maternal and child health/Long-term impact
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