摘要
白癜风是一种常见的色素脱失性皮肤病,其发病及发展是由遗传、氧化应激、炎症和环境因素共同作用的结果.既往常规治疗包括遮盖、外用皮质类固醇、外用钙调磷酸酶抑制剂、口服皮质类固醇、光疗和外科手术等,但均存在不同的局限性.近年来,随着对白癜风发病机制研究的深入,Janus激酶(Janus kinase,JAK)抑制剂在白癜风的治疗方面展现出了巨大的潜力.研究发现,JAK抑制剂通过抑制JAK-STAT信号通路,能够调节免疫反应、促进黑素细胞再生与迁移,从而改善白癜风患者的皮损状况.多项临床试验也证实了 JAK抑制剂治疗白癜风的有效性及安全性.然而,其长期疗效及潜在不良反应仍需进一步研究和探讨.总体而言,JAK抑制剂为白癜风的治疗提供了新的策略和方向.本文综述了JAK抑制剂在白癜风治疗中的研究进展,包括其作用机制、临床应用及疗效评价等方面,供临床使用参考.
Abstract
Vitiligo is a prevalent dermatological condition characterized by depigmentation of the skin,its etiology and progression are influenced by a combination of genetic,oxidative stress,inflammatory,and environmental factors.Traditional treatments encompass a variety of options such as camouflage,topical corticosteroids,topical calcineurin inhibitors,oral corticosteroids,phototherapy,and surgical procedures,each with distinct limitations.In recent years,with the in-depth researchon the pathogenesis of vitiligo,Janus kinase(JAK)inhibitors have shown great potential in the treatment of vitiligo.Researches have demonstrated that JAK inhibitors can modulate immune response,facilitate melanocyte regeneration and migration through the inhibition of the JAK-ST AT signaling pathway,ultimately leading to the amelioration of skin lesions in individuals with vitiligo.Furthermore,numerous clinical trials have substantiated the effectiveness and safety of JAK inhibitors in the management of vitiligo.However,future studies and discussions are necessary on its long-term efficacy and potential side effects.Overall,JAK inhibitors provide new strategies and directions for the treatment of vitiligo.This article provided an overview of the research advancements in the use of JAK inhibitors for treating vitiligo,encompassing their mechanism of action,clinical utilization,and effectiveness assessment,and an reference for clinical practice.
国家科技期刊平台
NSTL
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