B类1型清道夫受体介导的高密度脂蛋白在年龄相关性黄斑变性中的研究进展
Advances in uptake of high-density lipoprotein by scavenger receptor class B type 1 in age-related macular degeneration
李艳艳 1郑乐民 2杨娜娜 1付艺文 2孔翎宇 3范华菊 4王祥慧1
作者信息
- 1. 山东第二医科大学生命科学与技术学院,山东 潍坊 261053
- 2. 北京大学基础医学院,北京 100191
- 3. 苏州大学体育学院,江苏 苏州 215021
- 4. 山东第二医科大学心理学院,山东 潍坊 261053
- 折叠
摘要
随着年龄的增长,机体胆固醇代谢失调和叶黄素水平异常易导致视网膜异常脂质沉积和玻璃膜疣,进而增加年龄相关性黄斑变性(age-related macular degeneration,AMD)的患病风险.视网膜细胞上的B类 1 型清道夫受体(scaven-ger receptor class B type 1,SR-B1)在脂质代谢和视网膜保护中至关重要.组织细胞表面的 SR-B1 通过识别并结合细胞外的高密度脂蛋白(high-density lipoprotein,HDL),将游离胆固醇逆向转运至肝脏,对维持全身包括视网膜的脂质代谢平衡与避免脂质沉积至关重要.此外,HDL同样作为转运体参与叶黄素的视网膜转运过程.叶黄素,以其独特的蓝光过滤和抗氧化功能,减少蓝光对视网膜的潜在损伤并清除有害的氧自由基,发挥保护视网膜的作用.本综述将详细探讨 SR-B1 在视网膜中的作用,尤其是在协助胆固醇清除和叶黄素抗氧化防御方面的重要性,并评述 SR-B1 以及携带的有益成分如HDL和叶黄素对缓解 AMD发病的机制与最新研究进展.
Abstract
With aging,dysregulated cholesterol metabolism and abnormal lutein levels in the body are prone lead to retinal lipid deposition and drusen formation,increasing the risk of age-related macular degeneration(AMD).Scavenger receptor class B type 1(SR-B1)expressed on retinal cells plays a crucial role in lipid metabolism and retinal protection.Surface expression of SR-B1 on tissue cells enables the recognition and binding of extracellular high-density lipoprotein(HDL),facilitating the reverse transport of free cholesterol to the liver,which is vital for maintaining systemic lipid metabolism balance,including the retina,and preventing lipid deposition.Furthermore,HDL acts as a transporter for lutein in the retinal transport process.Lutein,with its unique blue light filtering and antioxidant properties,reduces potential damage from blue light to the retina and clears harmful oxygen free radicals,thereby exerting a protective effect on the retina.This review will extensively explore the role of SR-B1 in the retina,particularly its significance in assisting cholesterol clearance and lutein's antioxidant defense.Additionally,it will discuss the mechanisms and advances related to SR-B1 and beneficial components such as HDL and lutein in alleviating the pathogenesis of AMD.
关键词
B类1型清道夫受体/高密度脂蛋白/年龄相关性黄斑变性/胆固醇/视网膜Key words
Scavenger receptor class B type 1/High-density lipoprotein/Age-related macular degeneration/Cholesterol/Retina引用本文复制引用
基金项目
国家自然科学基金(81600360)
山东省自然科学基金(ZR2020KH008)
出版年
2024
国家科技期刊平台
NSTL
万方数据