The global population aging poses new challenges and requirements for improving health and preventing age-related diseases in older people.Long-lived individuals,due to their extended lifespans and ability to delay or even evade major age-related diseases,serve as exceptional natural models for studying healthy aging in humans.Through systematic research on long-lived populations,uncovering their potential mechanisms for healthy aging protection and related regulatory factors is crucial for developing strategies to delay aging and prevent age-related diseases.This review discusses the scientific value of long-lived populations,and summarizes recent advances in elucidating the biological basis of healthy aging based on the studies of these populations,particularly the application of multi-omics technologies in identifying genes and molecular pathways associated with longevity.Moreover,further research directions in this field are discussed,including longitudinal tracking studies and integration of multi-omics data,aiming to provide new scientific foundations for extending human lifespan and improving quality of life in old age.
维普
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