CD34 is the major membrane surface marker of hematopoietic stem/progenitor cells,and the core index for evaluating and selecting donor grafts in clinical hematopoietic stem cell transplantation(HSCT).However,the biological function of CD34 remains poorly understood.Functional studies of CD34 have revealed its important role in mediating adhesion,whether it functions as a facilitator or an inhibitor has not yet been determined.As a highly glycosylated type Ⅰ transmembrane protein,the post-translational modifications such as glycosylation and phosphorylation may play an important role in the regulation of CD34 conformation and function.Our previous research has identified the covalent active sites and phosphorylation sites of CD34 and their potential functions.In this review,a brief introduction and prospection on the molecular research progress of CD34 through combining basic research results was presented.
维普
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