中国医学前沿杂志(电子版)2024,Vol.16Issue(9) :48-55.DOI:10.12037/YXQY.2024.09-08

自体造血干细胞移植治疗急性髓系白血病——理念与方案的创新

Autologous hematopoietic stem cell transplantation for acute myeloid leukemia:innovations in concepts and protocols

陈斌 王涛
中国医学前沿杂志(电子版)2024,Vol.16Issue(9) :48-55.DOI:10.12037/YXQY.2024.09-08

自体造血干细胞移植治疗急性髓系白血病——理念与方案的创新

Autologous hematopoietic stem cell transplantation for acute myeloid leukemia:innovations in concepts and protocols

陈斌 1王涛1
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作者信息

  • 1. 山西医科大学第三医院,山西白求恩医院(山西医学科学院),同济山西医院)血液内科,山西太原 030032
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摘要

自体造血干细胞移植(autologous hematopoietic stem cell transplantation,auto-HSCT)是治疗急性髓系白血病(acute myeloid leukemia,AML)的有效手段,尤其是对于首次完全缓解预后良好组、部分预后中等组的AML、复发后再次完全缓解的急性早幼粒细胞白血病及某些特殊核型的AML患者.然而,尽管auto-HSCT在这些情况下显示出显著的疗效,但治疗过程中仍可能遇到诸多挑战和并发症,这要求医疗团队不断探索和优化治疗策略以提高患者的治愈率和生活质量.基于此,本文将综述auto-HSCT治疗AML的最新理念和方案,以期为进一步优化该治疗方式提供潜在的策略.

Abstract

Autologous hematopoietic stem cell transplantation(auto-HSCT)is an effective treatment for acute myeloid leukemia(AML),particularly for AML with good prognosis in first complete remission,some with partial intermediate prognosis,those with acute promyelocytic leukemia(APL)who achieve a second complete remission(CR2)after relapse,and patients with certain specific karyotypes of AML.However,although auto-HSCT have shown significant efficacy in these cases,many challenges and complications may still be encountered during the treatment,which requires medical teams to continuously explore and optimize treatment strategies to improve patients'cure rate and quality of life.Based on this,this article will review the latest concepts and protocols of auto-HSCT for AML,with the aim of providing potential strategies for further optimization of this treatment approach.

关键词

急性髓系白血病/自体造血干细胞移植/治疗/临床管理

Key words

Acute myeloid leukemia/Autologous hematopoietic stem cell transplantation/Therapy/Clinical management

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基金项目

山西省自然科学面上基金项目(202203021211070)

出版年

2024
中国医学前沿杂志(电子版)
人民卫生出版社有限公司

中国医学前沿杂志(电子版)

CSTPCDCSCD北大核心
影响因子:1.088
ISSN:1674-7372
参考文献量4
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