Psoriasis,as a common chronic immune system-mediated inflammatory skin disease,occurs at any age.Skin stem cells have the advantages of low immunogenicity,anti-inflammatory and multidirectional differentiation potentials,and thus have received extensive attention from scholars,and several basic studies and clinical trials on stem cell therapy for psoriasis have been conducted.This article reviews the research progress of different types of stem cells in the skin in the pathogenesis and treatment of psoriasis,aiming to promote the exploration process of stem cells in the mechanism of psoriasis and further research on stem cell therapy.