Helicobacter pylori(Hp)is a microaerobic gram-negative bacterium that colonizes the human gastric mucosa and is one of the important pathogenic factors in the occurrence of gastric mucosal diseases.In clinical patients with refractory Hp infection,the occurrence of refractory Hp infection is closely related to the Hp resistance gene and the genotype of the liver drug enzyme system.This paper systematically and comprehensively introduces the effect of common Hp resistance genes and patient CYP2C19 gene polymorphism on the treatment effect of Hp infection.By combing the relevant literature,we briefly describe the resistance mechanism of commonly used antibiotics.It also introduces that in high-resistant areas such as metronidazole,new programs such as high-dose combination therapy may be more effective Hp eradication treatment programs and improve the Hp eradication rate.This paper provides some reference for the formulation and implementation of treatment programs for refractory Hp infection patients in China,and provides references for an in-depth study on the mechanism of drug resistance in refractory Hp infection.
维普
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