Construction of warning model for bleak prognosis of acute ischemic stroke treated with intravenous thrombolysis
Objective To analyze the adverse prognostic factors for acute ischemic stroke(AIS)treated with intravenous thrombolysis,and construct a warning model to provide a basis for the prevention and treatment of complications.Methods A total of 256 AIS patients were collected and treated with intravenous thrombolysis within 4.5 h after cerebral hemorrhage and underwent DWI examination within 1 h after medication.Three months after treatment,they were divided into poor prognosis group(n=82,MRS score>2)and good prognosis group(n=174,MRS score≤2).Logistic regression analysis was used to analyze the adverse prognostic factors for constructing the warning model whose predictive efficacy was evaluated with ROC curve.Results Low DWI-ASPECTS and high NIHSS score were both risk factors for poor prognosis(P=0.01).The ROC curve analysis showed that for predicting poor prognosis,the model had sensitivity,specificity,positive and negative rates of 92%,47%,45%,92%in NIHSS score≥5,79%,80%,65%,89%in DWI-ASPECTS score<8,and 93%,73%,69%,94%in NIHSS score≥5 and DWI-ASPECTS score<8,with significant differences(P<0.01).Conclusion High baseline NIHSS score and low baseline DWI-ASPECTS score are the risk factors for poor prognosis in AIS,and the combined construction of a warning model is helpful to prevent and treat complications after intravenous thrombolysis.
acute ischemic strokeintravenous thrombolysisNIHSSDWI-ASPECTSwarning model
NETL
NSTL
万方数据
维普
