Quantitative evaluation of rheumatoid synovitis with TIC analysis of DCE-MRI image
Objective To improve the diagnostic sensitivity to rheumatoid arthritis(RA)by quantitatively evaluating and visualizing the shape and quantity of synovial pannus,especially inflammatory pannus,thereby providing reliable evidence for clinical medication guidance.Methods The wrists of 18 patients with RA confirmed by clinicopathology were examined with dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI),and the region of interest was delineated for the 4th phase of the enhanced image.Spearman correlation analysis was used to evaluate the correlations of time-intensity curves(TIC)parameters,including early enhancement rate(MSI),enhancement amplitude difference(MSD),time to peak,tangent slope of fitted curve tail,and determine the independent feature which was then used to define the type of curves(typeⅠ,slow enhancement;typeⅡ,fast enhancement followed by washout phase;typeⅢ,fast enhancement followed by plateau phase;typeⅣ,fast enhancement followed by slow enhancement increase).The volume of each type of TIC in ROI was calculated,and then compared with RAMRIS score for determining the TIC with the strongest correlation.Based on the characteristics of the selected curve,the quantitative classification of synovitis and two-dimensional multi-section color coding were carried out.Results MSI had significant positive correlation with MSD,and the volume of typeⅡTIC was correlated with RAMRIS score(r=0.812),indicating that in DCE-MRI image,the volume of type Ⅱ TIC was consistent with the type of synovitis pannus.Conclusion Statistical analysis of TIC is convenient for doctors to accurately and quantitatively analyze inflammatory pannus,providing important clinical information for diagnosis of disease severity and comparison before and after drug treatment in patients with RA.
NETL
NSTL
万方数据
维普
