基于振幅整合脑电图评价亚低温治疗新生儿缺氧缺血性脑病
Assessment of outcome in hypothermia therapy for neonatal hypoxic-ischemic encephalopathy using amplitude-integrated electroencephalography
黄俊 1徐学涛 1曾利明 1杨彩云1
作者信息
- 1. 安徽医科大学附属巢湖医院,安徽合肥 238100
- 折叠
摘要
目的:通过对振幅整合脑电图的分析,评估亚低温治疗新生儿缺氧缺血性脑病的效果.方法:回顾性分析59例中重度新生儿缺氧缺血性脑病患儿的临床资料,根据治疗方案不同分为观察组(n=31,亚低温治疗)和对照组(n=28,常规治疗).采用卡方检验、独立样本t检验和单因素Mann-Whitney U检验进行组间差异分析.结果:经过治疗后两组患儿下边界振幅在治疗24 h、睡眠觉醒周期及总评分在治疗72h后具有显著性差异(P<0.05).治疗后48h和72 h,亚低温治疗组患儿神经特异性醇烯化酶与对照组相比具有显著差异(P<0.05).结论:早期使用亚低温治疗可以显著改善新生儿缺氧缺血性脑病患儿的脑部功能,降低神经特异性醇烯化酶水平.
Abstract
Objective To evaluate the efficacy of hypothermia therapy in neonates with hypoxic-ischemic encephalopathy(HIE)through the analysis of amplitude-integrated electroencephalography.Methods A retrospective analysis was conducted on 59 neonates with moderate to severe HIE.They were divided into observation group(n=31,hypothermia therapy)and control group(n=28,conventional therapy)according to different treatment protocols.Chi-square test,independent sample t-test,and one-factor Mann-Whitney U test were used for intergroup difference analysis.Results Significant differences between two groups were observed in lower boundary amplitude after 24 h of treatment,sleep-awake cycle after 72 h of treatment,and total scores after 72 h of treatment(P<0.05).After 48 and 72 h of treatment,the neonates in hypothermia therapy group had obviously lower neuro-specific enolase level than those in control group(P<0.05).Conclusion Early application of hypothermia therapy can significantly improve cerebral function in neonates with HIE and lower the neuro-specific enolase level.
关键词
新生儿缺氧缺血性脑病/亚低温治疗/振幅整合脑电图/神经特异性醇烯化酶Key words
neonatal hypoxic-ischemic encephalopathy/hypothermia therapy/amplitude-integrated electroencephalography/neuron-specific enolase引用本文复制引用
基金项目
安徽省重点研发计划(202204J07020860)
出版年
2024
NETL
NSTL
万方数据