西达本胺维持治疗预防外周T细胞淋巴瘤自体造血干细胞移植术后复发的临床观察
Clinical observation of sidabendamine maintenance therapy to prevent recurrence of peripheral T cell lymphoma after autologous hematopoietic stem cell transplantation
刘艳 1王倩1
作者信息
- 1. 淄博市中心医院,山东淄博 255036
- 折叠
摘要
目的 讨论西达本胺维持治疗预防外周T细胞淋巴瘤自体造血干细胞移植术后复发的临床观察.方法 入选48例外周T细胞淋巴瘤自体造血干细胞移植术患者主要于2017年1月-2020年6月接受诊疗,以自体造血干细胞移植术后是否接受西达本胺维持治疗分为对照组24例与研究组24例.对照组未接受持续性维持治疗,研究组接受西达本胺治疗.观察指标:术后2年病情客观缓解率、术后2内复发率、研究组西达本胺不良反应情况.结果 研究组术后2年病情客观缓解率为70.83％,明显高于对照组术后2年病情客观缓解率的41.67％,差异有统计学意义(P＜0.05).研究组术后2年复发率为25％,明显低于对照组术后2年复发率的54.17％,差异有统计学意义(P＜0.05).24例研究组患者接受西达本胺治疗1个月内有8例发生血液学不良反应,治疗期间还有6例胃肠道反应、6例乏力、1例心脏毒副反应、1例肝肾轻度损害.结论 西达本胺维持治疗预防外周T细胞淋巴瘤自体造血干细胞移植术后复发有良好效果,可显著提高患者术后病情客观缓解率,不良反应轻.
Abstract
Objective To discuss the clinical observation of sidabendamine maintenance therapy in the prevention of recurrence of peripheral T-cell lymphoma after autologous hematopoietic stem cell transplantation.Methods A total of 48 patients with peripheral T-cell lymphoma undergoing autologous hematopoietic stem cell transplantation were enrolled from January 2017 to June 2020.They were divided into control group(n=24)and study group(n=24)according to whether they received sidabenamine maintenance therapy after autologous hematopoietic stem cell transplantation.The control group did not receive continuous maintenance treatment,and the study group received sidabenamine treatment.Observation indexes:objective remission rate 2 years after operation,recurrence rate within 2 years after operation,and adverse reactions of sidabenamine in the study group.Results The objective remission rate in the study group was 70.83％,which was significantly higher than 41.67％in the control group,and the difference was statistically significant(P＜0.05).The recurrence rate within 2 days after operation in the study group was 25％,which was significantly lower than 54.17％in the control group,and the difference was statistically significant(P＜0.05).Among the 24 patients in the study group,hematological adverse reactions occurred in 8 cases,gastrointestinal reactions in 6 cases,fatigue in 6 cases,cardiac side effects in 1 case,and mild liver and kidney damage in 1 case within 1 month after receiving sidabenamine treatment.Conclusion Sidabenamine maintenance therapy has a good effect on preventing recurrence of peripheral T-cell lymphoma after autologous hematopoietic stem cell transplantation.It can significantly improve the objective remission rate of patients after surgery,and has mild adverse reactions.
关键词
西达本胺/外周T细胞淋巴瘤/自体造血干细胞移植/复发Key words
Cedarbenamine/Peripheral T-cell lymphoma/Autologous hematopoietic stem cell transplantation/Recurrence引用本文复制引用
出版年
2023
NETL
NSTL
维普
万方数据