Exposure levels of perfluorinated and polyfluoroalkyl compounds in umbilical cord blood in Linyi,China
Objective To analyze the concentration levels of perfluorinated and polyfluoroalkyl compounds(PFAS)in umbilical cord blood of pregnant women in Linyi area,so as to evaluate the fetal PFAS load more comprehensively.Methods Based on the prospective birth cohort study from January 2019 to December 2021,among 420 mother-infant cohorts who joined the birth cohort in Linyi,Shandong Province,120 full-term infants born naturally through vaginal delivery were selected as the research objects.The concentrations of 29 kinds of PFAS in umbilical cord blood were determined by liquid chromatography-tandem mass spectrometry(UPLC-MS/MS)to assess their exposure levels.Results 6:2FTS was not detected in the sample,and the PFAS with low detection rate in the sample were:4:2 FTS(17.5%),8:2 FTS(6%),FOSA(15%),NADONA(10%),N-EtFOSAA(3%),N-MeFOSAA(10.8%),PFNS(4%),∑m2-PFOS(13%),PFPeS(20%).The other 19 kinds of PFASs were:6:2 Cl-PFESA,PFBA,PFDoA,PFHpS,L-PFHxS,PFNA,PFOA,L-PFOS,6m-PFOS,3,4,5m-PFOS and PFUdA,and the detection rates were all 100%.The detection rates of HFPO-DA,PFBS,PFDA,PFHpA,PFHxA,1m-PFOS,PFPeA and PFTeDA were 77.1%～100%.Exposure concentration of PFAS:the median concentration of PFOA was the highest(3.234 ng/mL),followed by 6:2 Cl-PFESA(1.351 ng/mL),L-PFOS(0.935 ng/mL),PFNA(0.268 ng/mL),3,4,5m-PFOS(0.191 ng/mL),L-PFHxS(0.170 ng/mL),PFUdA(0.122 ng/mL),and the median concentration of other detected compounds was 0.001～0.099 ng/mL.Conclusion Among the 29 kinds of PFASs detected in umbilical cord blood in Linyi area,PFOA exposure level is the highest,followed by 6:2 Cl-PFESA exposure level,which has exceeded the PFOS exposure level in previous studies.It is of great significance to comprehensively evaluate the load status of fetal PFAS and provide basic data for further continuous monitoring of fetal growth and development and health risk assessment by PFSA in the future.
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