Predictive value of nuchal translucency for screening severe α-thalassemia in the first trimester pregnancy
Objective To study the application values of nuchal translucency(NT)in predicting severe α-thalassemia at 11～13+6 weeks of gestation.Methods Retrospective analysis of the clinical data of 974 pregnant women who underwent interventional prenatal diagnosis at Huizhou First Maternal and Child Health Care Hospital from January 2017 to December 2022,with both spouses who are the same type of α-thalassemia gene carriers.According to the results of prenatal α-thalassemia genetic test,all cases were divided into control group(normal fetus),silent group(silent fetus),mild group(mild fetus),moderate-1 α-thalassemia group(CS/QS intermediate fetus),moderate-2 α-thalassemia group(other intermediate fetus)and severe α-thalassemia group(severe fetus).The ultrasound technique was used to measure the crown-rump length(CRL)and NT to compare the difference between the groups.The area under the cure(AUC)was calculated and the optimal cut-off value for NT to predict severe α-thalassemia was determined by drawing the receiver operating characteristic(ROC)curve.Results Except for the moderate-1 group,the NT MOM in the severe group was significantly higher than those in the other groups,the difference was statistically significant(P<0.05).No significant differences were observed in NT MOM among the other groups except for the severe group(P>0.05).ROC curve analysis showed that the optimal cut-off value for NT to predict severe α-thalassemia was 1.23 MOM,and the sensitivity and specificity was 54.05%and 80.67%,respectively.Conclusion The NT in the first trimester pregnancy can effectively predict severe and non-severe α-thalassemia fetuses,and the optimal cut-off value can provide a clinical reference.
NETL
NSTL
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