The predictive value of serum factors for infertility in patients with endometriosis
Objective To explore the predictive value of serum factors for infertility in patients with endometriosis(EMS).Methods A total of 110 patients with EMS who underwent laparoscopic surgery and pathologically diagnosed in Caofeidian District Hospital from August 2020 to September 2021 were included in the study.They were divided into EMS group(n =60)and EMS infertility group(n =50)according to whether they were complicated with infertility,and healthy subjects in the same period were taken as control group(n =50).The levels of serum factors including interleukin-6(IL-6),interleukin-37(IL-37),tumor necrosis factor-α(TNF-α),transforming growth factor-β(TGF-β)in 3 groups were compared,and the correlation between serum factors was analyzed by Pearson method.The predictive value of serum factors for EMS infertility was analyzed by receiver operating characteristic curve(ROC).Results The serum levels of IL-6,IL-37,TNF-α and TGF-β in EMS group and EMS infertility group were higher than those in control group,and those in EMS infertility group were higher than those in EMS group,the differences were statistically significant(P<0.05).Pearson analysis showed that serum IL-6,IL-37,TNF-α and TGF-β were positively correlated(P<0.05).ROC curve analysis showed that the AUC of serum IL-6,IL-37,TNF-α and TGF-β in predicting EMS and EMS infertility were 0.715,0.687,0.728 and 0.716,respectively.The sensitivity(97.8%)and specificity(75.0%)of combined detection were higher than those of single detection(P<0.05).Conclusion Serum IL-6,IL-37,TNF-α and TGF-β showed high predictive value for EMS and EMS infertility,and the serum factors were positively correlated.
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