Analysis of the therapeutic effect of dienogest combined with goserelin in the treatment of adenomyosis
Objective To analyze the effect of dienogest combined with goserelin in the treatment of patients with adenomyosis(AM).Methods A total of 142 patients with AM in Shanghai Baoshan District Luodian Hospital from April 2019 to March 2022 were selected and randomly divided into the observation group and the control group,with 71 cases in each group.The control group was treated with goserelin,and the observation group was combined with dienogest on the basis of the control group.The treatment effect was counted,and the degree of dysmenorrhea,uterine volume,menstrual flow,serum estradiol(E2),prostaglandin E2(PGE2),vascular endothelial growth factor(VEGF),membrane-type matrix metalloproteinase 1(MT1-MMP)levels,interleukin-8(IL-8),tumor necrosis factor-α(TNF-α)levels and adverse reactions were compared between the two groups before treatment and at 1 month and 3 months after treatment.Results The total effective rate in the observation group(95.77%)was higher than that in the control group(85.92%)(P<0.05).The menstrual flow,uterine volume,dysmenorrhea degree,serum E2,PGE2,VEGF,MT1-MMP,IL-8,and TNF-α levels in the two groups for 1 month and 3 months after treatment were lower than those before treatment,and the observation group was lower than the control group(P<0.05).The incidence of adverse reactions(9.86%)in the observation group was compared with the control group(7.04%),and there was no significant difference(P>0.05).Conclusion Dinogest combined with goserelin in the treatment of patients with AM is effective,it can reduce the degree of dysmenorrhea,reduce the volume of the uterus,improve irregular menstruation,reduce the level of estrogen,and inhibit the infiltration of endometrial lesions and inflammatory response,and it is safe and reliable.